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The protective effect of metformin

Wednesday, 28 August 2019 by System Administrator

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Researchers from University of Balikesir Report Details of New Studies and Findings in the Area of Antiemetic-Antivertigo Agents (The protective effect of metformin in scopolamine-induced learning and memory impairment in rats)

Disease Prevention Daily

08-22-19

2019 AUG 21 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Investigators discuss new findings in Drugs and Therapies - Antiemetic-Antivertigo Agents. According to news reporting originating from Balikesir, Turkey, by NewsRx correspondents, research stated, “Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. One of the most commonly prescribed oral antidiabetic drug, metformin, has been shown to have beneficial effects on restoring impaired cognitive function.”

Financial support for this research came from Balikesir Universitesi.

Our news editors obtained a quote from the research from the University of Balikesir, “In the present study, we investigated the effects of metformin on spatial memory in terms of alleviating scopolamine-induced learning and memory impairments in rats by using the Morris water maze (MWM) test and the modified elevated plus-maze (mEPM) test. Furthermore, we investigated the possible mechanisms of action of metformin in preventing cognitive dysfunction. Male Wistar rats received metformin (50, 100, or 200 mg/kg/day) via gavage feeding for three weeks. Scopolamine was administered intraperitoneally before the probe step of the MWM test or the acquisition session of the mEPM test. The learning and memory impairment induced by scopolamine was reversed by metformin. In addition, metformin improved the level of phosphorylated AMP-activated protein kinase and cAMP responsive element binding protein. However, metformin pretreatment had no impact on inhibiting the scopolamine-induced changes in acetylcholine levels. Furthermore, metformin exerted its antioxidant effect by significantly reversing scopolamine-induced changes in malondialdehyde, total antioxidant status, and superoxide dismutase levels in the hippocampus.”

According to the news editors, the research concluded: “Our results indicate that one of the most commonly used antidiabetic drug, metformin, has the potential to prevent the development of dementia and be a novel therapeutic drug for the amelioration of cognitive dysfunction in AD.”

For more information on this research see: The protective effect of metformin in scopolamine-induced learning and memory impairment in rats. Pharmacological Reports, 2019;71(5):818-825.

The news editors report that additional information may be obtained by contacting E. Aksoz, University of Balikesir, Faculty of Medicine, Dept. of Medical Pharmacology, Cagis Campus, Balikesir, Turkey. Additional authors for this research include S.S. Gocmez, T.D. Sahin, D. Aksit, H. Aksit and T. Utkan.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.pharep.2019.04.015. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

Articles featured in Life Extension Daily News are derived from a variety of news sources and are provided as a service by Life Extension. These articles, while of potential interest to readers of Life Extension Daily News, do not necessarily represent the opinions nor constitute the advice of Life Extension.

Invitation to the Annual General Meeting of the Cryonics Institute

Wednesday, 24 July 2019 by System Administrator

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Invitation to the Annual General Meeting

of the Cryonics Institute and Immortalist Society

3 P.M. Sunday, September 8th, 2019

 

The Annual General Meeting (AGM) of the Cryonics Institute will be held from

3 pm until 7 pm on Sunday, September 8th, 2019 at the Bravado Event Venue’s Grand Ballroom. 36217 S Gratiot Ave., Clinton Twp., MI 48035.

Phone: (586) 477-1240. www.bravadoevents.com

 

The AGM of the Immortalist Society will be held after the CI AGM on the same day at the same location.

 

A buffet lunch will be provided, so please be sure to RSVP to ensure we have a seat for you. You can email CIHQ@aol.com or call (586) 791-5961 to RSVP.

 

Tours of the CI facility will be available before the meeting from 12 pm until 2pm. We are located at 24355 Sorrentino Court, Clinton Twp., MI 48035.

 

Meetings offer an opportunity to see the facility, to meet other members, to get a sense of the status of the Cryonics Institute and Immortalist Society and to see Officers, Directors and Staff. Agenda items for the CI AGM will include President’s Report, Treasurer’s Report, and Investment Report. The results of the CI Board of Directors election will be announced.

 

For those who come a day early, an informal dinner will be held at 6 pm on Saturday evening at Sajo’s Restaurant. 36470 Moravian, Clinton Twp., MI 48035. Phone: (586) 792-7256. www.Sajos.net.

 

The AGMs are open to our membership and to those who are interested in the Cryonics Institute.  Out of town guests can book a discounted room at the Hampton Inn or the Red Roof Inn.

 

The Hampton Inn is located at 33680 Gratiot Ave., Clinton Twp., MI 48035. Call (586) 792-1500 and tell them you are a CI member to receive a discount.

 

The Red Roof Inn is located at 31800 Little Mack Ave., Roseville, MI 48066. Call

(586) 296-0310 and use code VP#624467 to receive a discount or visit: www.redroof.com/deals/partner/Cryonics_Institute

 

A list of other hotels near the CI facility can be obtained from the Cryonics Institute website: www.cryonics.org/resources/hotels-near-the-cryonics-institute

It is election time again.

Saturday, 13 July 2019 by System Administrator

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It is election time again.

Hello All

It’s that time of the year again. The cryonics Institute is a very unique cryonics organization in that our directors are elected directly out of our membership by our membership. The sitting directors in turn elect the officers as so forth. All directors and officers are members just like you who are themselves signed up for cryonic suspension. We all have a direct vested interest in the success of our mission.  This serves to draw us together like a family with the same goal of being revived some day in the future.

It is important to learn about candidates and to vote if want to ensure for CI’s future. Do your due diligence and ask around and learn about the candidates. CI’s stability depends on good quality directors passing the torch on as we move into the future.

If you as an eligible member seek to run for office then it is time to get your paperwork in and get yourself on the ballot. All of CI’s rules, bylaws, and so forth are published on this official website. Eligible candidates should seek out information and ask questions and learn so that they can best represent the membership.  It is not an easy job sometimes and it is a voluntary position but if you are passionate about CI and its security then I urge you to get involved. It is the responsibility of all incumbent directors and challengers to get their ballots in on time, learn and understand CI bylaws, and inquire about deadlines and qualifications for the directorship positions. Good luck and best wishes to all.

 

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